Neuroscientists at the Ohio university have given a new insight into neuron vulnerability. This could allow Research in developing new solutions to avoid and treat neurodegenerative disease. The study was published in the journal Act Neuropathologica.
Harry Fu, the lead author of the study said that comprehending some neurons in a specific region that has the higher possibility of degeneration is of importance for Alzheimer’s disease. This study was based on the old Research about tau pathology and memory deficits. The of the study focus on understanding the subtypes of neurons that are more susceptible to the buildup of the protein that leads to Alzheimer’s disease. The Research also looks into the molecular and cellular mechanisms and their causes of neuronal weakness.
Wolframin is a protein that is encoded by the WFS1 gene in humans. Wolframin expressing excitatory neurons are more vulnerable in the entorhinal cortex, which has a hub for memory, navigation, and time perception. The Research also used both human brain and mouse models to understand the WFSI genes. They also used this to demonstrate that WFSI can help to reduce the tau pathology and other neurogenerative diseases through the regulation of stress to the abnormal buildup of the protein.
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